Effect of 5,4'-dihydroxy-3,6,7,8-tetramethoxyflavone and 5,3'-dihydroxy-3,6,7,8,4'-pentamethoxyflavone on mitochondrial function in living K562 and K562/adr cancer cells

Abstract

In the previously study we reported speciation of methoxyflavone including 5,4'-dihydroxy-3,6,7,8-tetramethoxyflavone (WP279) and 5,3'-dihydroxy-3,6,7,8,4'-penta methoxyflavone (WP283) in a physiological solution and their anticancer property. The objective of this study was to determine the effect of 5,4'-dihydroxy-3,6,7,8-tetramethoxyflavone and 5,3'-dihydroxy-3,6,7,8,4'-pentamethoxyflavone on mitochondrial membrane potential in drugsensitive, K562 and drug-resistance, K562/adr cancer cell lines by using spectrofluorescence technique. The result shows that WP279 and WP283 slightly increased the mitochondrial membrane potential in K562 and K562/adr due to the concentration.